2116. A Hybrid Metaheuristic for Chemotherapy Scheduling and Medication Production Under Uncertainty
Invited abstract in session WD-11: Chemotherapy scheduling, stream OR in Healthcare (ORAHS).
Wednesday, 14:30-16:00Room: Clarendon SR 1.03
Authors (first author is the speaker)
| 1. | Katrin Kopfer
|
| Business Decisions and Analytics, University of Vienna | |
| 2. | Karl Doerner
|
| Department of Business Decisions and Analytics, University of Vienna | |
| 3. | Pamela Nolz
|
| Mobility Department - Dynamic Transportation Systems, AIT Austrian Institute of Technology |
Abstract
Infusion-administered chemotherapy is one of the most common treatments in curative and palliative cancer care. Usually administered in outpatient clinics, treatments follow a patient-specific regimen including infusion appointments combined with rest periods over a time horizon of several weeks to months and specifications on the highly individual, perishable and often costly medications. We introduce the Chemotherapy Optimization Problem (COP), which integrates patient appointment scheduling and medication production planning while accounting for stochastic patient cancellations. Patients are scheduled for their appointments in an inter- and intraday setting, determining both, their treatment days and specific times. The daily medication production includes the decision of producing patient-specific medications in advance or on demand, creating a trade-off between potential drug waste and patient waiting times. Limited resources such as consultation rooms and infusion seats restrict the integrated problem; thus, we optimize the COP to maximize resource utilization and minimize production waste using a weighted sum. We introduce new instance sets and solve the COP using a Large Neighborhood Search for tactical planning combined with a Constraint Programming Model for efficient operational scheduling. Further, we analyse the impact of stochastic patient cancellations on schedule robustness, highlighting the importance of resilient planning in outpatient oncology clinics.
Keywords
- Health Care
- Metaheuristics
- Scheduling
Status: accepted
Back to the list of papers